More Evidence of the Skin Rejuvenating Effects of LED Therapy

[Yesterday I reviewed some of the broadly accepted research into the Collagen Boosting Effects of LED Phototherapy.]

A slowdown in collagen production is not the only reason that skin ages. Enzymes called matrix metalloproteinases, or MMPs, also contribute by breaking down the skin’s support matrix.

Reduction in MMPs with LED Therapy
Recent research indicates that LED photodynamic therapy not only increases collagen production, but may also inhibit enzymes which destroy collagen (Barolet et al., 2009).

This study employed LED light delivered in a sequential pulsing mode at 660 nm because it is a well-absorbed wavelength that penetrates through the epidermis to the dermal layer where collagen in produced.

In Vitro
Human Reconstructed Skin (HRS), developed for this research was used for the in vitro portion of the study.

HRS has some advantages over an in vivo trial:

• It allows testing for changes over an extended period of time under strictly controlled conditions; and
• Samples can be modeled to replicate gender- and age-specific characteristics.

Eleven LED treatments were given over 4 weeks and compared with untreated control specimens for collagen and MMP production.

The treated HRS specimens showed an average 31% (range 5 to 81%) increase in collagen and 18% (range 3 to 27%) decrease in MMP levels as compared to the untreated control specimens.

No histological differences were found in the new collagen, i.e., the cells stimulated by LED therapy were normal.

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Come back tomorrow for the In Vivo Results from the Barolet Study.

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